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Significance of Helicoll® – Audio-Visual Presentation

Helicoll®, an Advanced Skin Substitute
See how Helicoll® compares to other skin substitutes below:

Helicoll® Prep & Application


For surgical settings: Helicoll® can be sutured or stapled in place as needed.


Helicoll® is always to remain directly onto the wound and never removed or wiped off during a dressing change.

Why Type-1 Collagen?


Type-1 Collagen that is a full molecule, purified, and uncross-linked provides 3,000 receptor sites per molecule for growth factors such as fibroblasts to attach to making it an excellent matrix for use in wound healing. Type-I Collagen is 97% the same across different species whereas Type-II & III is only 80% similar in the same species.

For instance, Type-I collagen is extremely similar, or the same, in human as it is in a cow or in a bird. Type-I is least immunogenic. The similarity of Type-I Collagen across species is believed to be the reason that you see a dramatic pain reduction with the use of Helicoll® with the most painful wounds such as donor sites and burns. Type-I Collagen does not cause an immunogenic response due to its lack of sulfur-containing amino acid cysteine. Type-III has more cysteine than Type-I, & Type-II has the highest concentration making Type-II & Type-III highly immunogenic.

What is Helicoll® made of?

How Helicoll® Collagen Differs From Other Collagen Dermal Replacements?

Collagen exposed during wound formation activates the clotting phase and facilitates the migration of the inflammatory cells to the wound bed. If the matrix made of collagen is native, pure and non-immunogenic, it will possess all the natural binding sites to all the cytokines, including epidermal growth factor (EGF), fibronectin, fibrinogen, histamine, platelet derived growth factor (PDGF), serotonin, and von Willebrand factor etc… A cross-linked or contaminated Type III collagen cannot effectively achieve such wound healing characteristics.

Additionally, a native collagen dressing also has cell membrane binding sites that would attract the neutrophil, for debris scavenging, bacteria destruction, and leukocytes along with the macrophages/monocytes, for wound healing via secretion of enzymes and cytokines for tissue reconstruction.

Subsequently, epithelialization, angiogenesis, granulation tissue formation, and collagen deposition are the principal steps in this anabolic portion of wound healing. It is also hypothesized that the native Type-I collagen creates adhesion sites for growth factors and it would trigger a phenomenon called “Cell Signal Transduction” through which the floating stem cells are converted to appropriate cell-lines to regenerate the damaged tissue.

The other collagen preparations, mostly contaminated with type-III collagen, elastin, lipids and other immunogenic proteins, following chemical cross-linking, that is required to minimize their immunogenicity, does not maintain the native chemistry of collagen and thereby loses its bioactivity and also other binding abilities and gets significantly impaired with its wound healing abilities.

The illustration below depicts the behavior of cross-linked collagen vs. non-crosslinked collagen.


Helicoll® Product Brochure & IFU

Helicoll® Technical and Clinical Info 2024

Helicoll® Innovative Technology, Design, Features, & Benefits

Helicoll® comparison with other FDA cleared products

Helicoll® Clinical & Technical Features

Helicoll® Clinical Studies and Evidence of benefits

Helicoll® Compared to other Products

Helicoll® Product Details

Helicoll® Unique Features

Helicoll® White Papers

Helicoll® White Paper on DFU

Helicoll® White Paper on Elastin Carcinogenicity

Helicoll® White Paper on NPWT

Helicoll® White Paper on Tissue Regen Bioactivity

Medical Billing Guide

Medical Billing Guide – Medicare

Medicare Recognized Helicoll as a High-Cost skin substitute since 2017

Helicoll® Product Price Catalog

Helicoll® Regulatory Info

Helicoll® FDA 510(k) Clearance

Encoll FDA Mfg License Facility Regn

Helicoll® 16 point MSDS

Helicoll® Trademark Registration

Small Business Certification Cert. No. 2024055

City of Fremont - Business License Certificate

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